Новый ИИ OpenAI способен клонировать голос человека из 15-секундного аудио

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Новый ИИ OpenAI способен клонировать голос человека из 15-секундного аудио

Компания OpenAI сообщила о готовности к внедрению нового ИИ-инструмента Voice Engine. С его помощью можно клонировать голоса людей на основе аудиозаписи их речи длительностью всего 15 секунд. При этом сгенерированные голоса звучат не только естественно, но и эмоционально и реалистично. Работа над технологией велась с 2022 года.

В компании заявили, что считают технологию полезной. Она может быть отличным решением для помощи при чтении и переводах. Кроме того, Voice Engine выглядит панацеей для всех, кто страдает дегенеративными расстройствами речи. В качестве примера разработчики рассказывают о том, как инструмент уже помог одному из таких пациентов успешно реализовать школьный проект. Но технология также вызывает и значительные опасения. OpenAI указывает на высокие риски, с которыми сопряжено ее широкое внедрение.

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Мошенники, скорее всего, будут активно использовать возможности Voice Engine или ее аналогов в своих интересах. Чтобы снизить риски, компания установила несколько правил, которые должны неукоснительно соблюдать все, кто намерен использовать сервис. Прежде всего, требуется уведомлять аудиторию, что голос создан нейросетью. Также предусмотрены водяные знаки и система упреждающего мониторинга. Также будет действовать запрет на клонирование голосов известных личностей. И, конечно, никто не имеет права использовать чей-то голос без его согласия.

Точной даты, когда начнется развертывание Voice Engine, пока нет — однако известна стоимость подписки. Она составит 15 долларов за 1 000 000 озвученных символов — это сопоставимо с полноценной книгой. Также ожидается подписка на HD-версию сервиса за 30 долларов, но каковы ее преимущества пока не сообщается.

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  46. TA1 is rapidly absorbed, achieving peak serum concentrations
    within two hours. Sodium bicarbonate buffers defend the delicate KPV tripeptide via acidic stomach environments.

    Extra intact peptide reaches the small intestine where absorption takes place efficiently into circulation. The peptide KPV isn’t a miracle restoration;
    however, it’s a smart support tool for people handling persistent intestinal infection. If you are
    working to build an intestine-friendly way of
    life that consists of nutrient-rich meals,
    stress management, and skilled care, this peptide may match proper in.
    Given its ability to reduce inflammation whereas supporting tissue regeneration, KPV is being more and
    more studied alongside well-known therapeutic peptides like BPC-157 and TB-500.
    KPV downregulates oxidative stress pathways and reduces reactive oxygen species (ROS),
    offering protection at the cellular level and enhancing tissue
    therapeutic, especially in the intestine, mind, and pores and skin. One of
    the notable research on KPV peptide highlights its efficacy towards bacterial strains
    similar to Staphylococcus aureus. Researchers have
    discovered that KPV reveals important antimicrobial exercise, which is believed to
    be because of its capacity to disrupt bacterial membranes, a common mechanism of action for so much of
    antimicrobial peptides [R].
    Let us pave the finest way for a pain-free tomorrow,
    the place people can reclaim their lives and rediscover the joy of living with out the shackles of continual
    ache. The contents of this web site, similar to textual content,
    graphics, photographs, and other materials contained on the website («Content») are
    for informational functions. Our web site isn’t supposed
    to be an alternative to skilled medical recommendation, diagnosis,
    or treatment from a licensed healthcare skilled. At All Times search the advice of a physician or other qualified
    well being provider with any questions you could have concerning a
    medical condition. One Other unique function of KPV is its capability to focus on the skin instantly.

    And yes, this alone may be what causes your leaky
    gut and your subsequent Ulcerative colitis.
    Natural killer (NK) cells are pivotal in inhibiting cancer progression by eradicating mutant cells
    through death receptors and cytotoxic granules. Nevertheless, within the TME, these NK cells incessantly exhibit exhaustion (Jia et al., 2023).
    Hence, ongoing research in PCa is concentrated on creating
    peptide-based immunotherapies geared toward reversing NK cell
    exhaustion and enhancing their cytotoxic capabilities. MetAP2, an effector protein of S100A4
    known to be concerned in angiogenesis, binds to S100A4 in a calcium-dependent manner.
    When calcium binds to S100A4, it undergoes a big conformational change, forming a hydrophobic binding pocket that can work together with MetAP2
    (Ochiya et al., 2015). The NBD peptide successfully blocks this binding pocket, thus inhibiting the interaction between S100A4
    and its effector proteins, together with MetAP2 (Takenaga et al., 2021).

    The human cathelicidin LL-37 serves a critical function in the innate immune
    system defending towards bacterial infections. LL-37 can interact with molecules of
    the cell wall and perforate cytoplasmic membranes resulting in bacterial cell death.
    In specific, the cathelicidin LL-37 is overexpressed
    in infected pores and skin in psoriasis, binds to extracellular
    self-DNA released from dying cells, and converts self-DNA in a potent stimulus for plasmacytoid dendritic cells (pDCs).
    Subsequently, pDCs secrete kind I interferons and trigger an auto-inflammatory cascade.

    Coli, and α-MSH was discovered to have antimicrobial
    activity against both planktonic and biofilm
    phenotypes of S. Pentosan PolysulfatePentosan is quite
    an incredible anti-inflammatory that can be utilized in circumstances of
    osteoarthritis as a weekly therapy. Studies have shown that it might possibly
    it could help improve cartilage is osteoarthritis joints.
    It has reduced pain an inflammation in osteoarthritis patients (Kumagai).
    It additionally works on infectious arthritis, which has been discovered extra incessantly in the us within the final decade (Herrero).
    This has been discovered to be a potent anti-inflammatory
    agent as properly that can be used to convey
    down irritation (Ghosh). This peptide has been mentioned
    to be a favourite among peptide medical doctors time and
    again.
    Analysis suggests potential synergistic effects between KPV
    and BPC-157 peptides, particularly in gastrointestinal
    and tissue repair functions. Both compounds show complementary anti-inflammatory
    mechanisms, with KPV focusing on melanocortin pathways and
    BPC-157 targeting development factor signaling. Mixture analysis protocols require careful consideration of dosing, timing, and
    interaction effects under acceptable laboratory conditions.
    Research signifies that KPV could affect key inflammatory
    cytokines like TNF-α and IL-6, which play vital roles
    in the inflammatory response.
    Some research suggest gastrointestinal results such as nausea and diarrhea might happen. However, these unwanted side effects are typically gentle and temporary, resolving on their own with out
    the need for intervention. It’s important for researchers to observe these
    effects to make sure the integrity of their research.
    This work ultimately led to the invention of tissue-specific peptides that might potentially influence gene expression and cellular perform.

    Its potential to serve as a analysis agent for gut-related inflammatory conditions is being explored in numerous
    studies. Gut health is a important aspect of total well-being, and analysis means that KPV peptide might play
    a major role in promoting a healthy gut. Studies indicate
    that KPV can potentially struggle inflammation within the intestine, making it a valuable asset in addressing gut inflammation. The peptide is suggested to help mucosal healing within the intestines,
    which is crucial for maintaining gastrointestinal health.

    If utilized in topical cream form, it could possibly doubtlessly prevent additional improvement of eczema,
    psoriasis and zits. The oral utility might be important in treating inflammatory
    diseases of hoses similar to ulcerative colitis, Crohn’s illness and inflammatory gut syndrome.
    In Accordance to numerous studies, KPV might doubtlessly
    accelerate wound healing and reduce the potential for scarring after surgery.
    This peptide expresses all the mentioned effects modified
    and considerably improved in relation to the original molecule.

    References:

    yaseen.tv

  50. Sermorelin and Ipamorelin are two peptide hormones that have become increasingly
    popular in the field of anti-aging medicine and athletic performance enhancement.
    Both work by stimulating the pituitary gland to release growth hormone (GH) naturally,
    but they differ in potency, duration of action, side-effect profile, and how quickly users might notice changes.
    The «before» state for many people who consider these peptides is often characterized by a
    plateau or decline in growth hormone levels, which can lead to
    reduced muscle mass, increased fat accumulation, diminished energy, slower recovery from exercise, and overall feeling of aging.

    Before beginning therapy with Sermorelin or Ipamorelin, most individuals typically experience one or
    more of the following:

    Reduced Energy Levels: A persistent fatigue that
    does not improve with sleep or nutrition.

    Muscle Loss: Noticeable decline in muscle tone and strength despite regular
    workouts.

    Increased Body Fat: Particularly around the abdomen and
    hips, often resistant to diet and exercise.

    Poor Sleep Quality: Difficulty falling asleep or staying asleep,
    leading to a vicious cycle of fatigue.

    Joint Pain and Stiffness: Less elasticity in tendons and ligaments, causing
    discomfort during routine activities.

    After starting treatment with either Sermorelin or Ipamorelin, many users report changes that can be grouped into several categories.
    The onset of these effects varies depending on individual metabolism, dosage, injection technique,
    and the specific peptide used, but typical timelines are outlined below.

    Hormonal Response and GH Levels

    Both peptides act as secretagogues: they bind to growth hormone-releasing hormone (GHRH) receptors in the pituitary gland.
    Sermorelin is a 29-amino acid analogue of GHRH, while
    Ipamorelin is a 5-residue hexapeptide that mimics ghrelin’s action on GH secretion but with higher selectivity
    for the growth hormone secretagogue receptor (GHSR).
    Because they mimic natural signals rather than directly stimulating GH receptors, their side-effect profiles are
    generally mild.

    Immediate Effect: Within a few hours of injection, blood tests may show a modest rise in circulating GH.
    The magnitude of increase is often lower than that achieved by exogenous growth
    hormone therapy but sufficient to stimulate downstream processes.

    Peak Levels: Sermorelin typically peaks around 1–2 hours after
    injection, whereas Ipamorelin can peak slightly
    earlier (30–60 minutes) due to its smaller size and faster absorption. The
    duration of elevated GH is roughly 4–6 hours for both peptides.

    Metabolic and Body Composition Changes

    After several weeks of consistent dosing—often 5–7 times per week—the metabolic
    effects become more apparent:

    Fat Loss: Users frequently report a reduction in visceral fat.
    This occurs because GH promotes lipolysis, mobilizing fatty acids from adipocytes into circulation for energy use.

    Muscle Gain and Strength: Muscle protein synthesis is enhanced by GH
    and insulin-like growth factor 1 (IGF-1), which is upregulated
    following peptide stimulation. A typical observation after 4–8 weeks is an increase in lean body mass, especially in the upper body and core musculature.

    Restoration of Metabolic Rate: Basal metabolic rate can rise modestly
    as GH supports mitochondrial function and thermogenesis.

    Recovery and Performance

    Athletes often choose Sermorelin or Ipamorelin to aid recovery:

    Reduced Muscle Soreness: The peptides help repair muscle tissue by
    promoting satellite cell activation, leading to less delayed
    onset muscle soreness after intense training sessions.

    Faster Regeneration of Tendons and Ligaments: GH encourages collagen synthesis,
    improving connective tissue strength and resilience.
    This translates into fewer injuries over time.

    Enhanced Endurance: Some users note improved stamina during
    cardio workouts, likely due to better glucose utilization and
    increased mitochondrial density in muscle cells.

    Sleep Quality and Mood

    Growth hormone is secreted in pulses during deep
    sleep stages (particularly slow-wave sleep). By normalizing GH secretion:

    Improved Sleep Architecture: Many people experience deeper
    REM cycles and fewer awakenings, leading to more restorative
    rest.

    Elevated Mood and Cognitive Function: GH influences neurotransmitter systems; users often report better focus, sharper memory recall, and
    an overall sense of well-being.

    Longevity and Cellular Health

    While research in humans is still evolving, preclinical studies suggest
    that sustained, physiologic levels of GH can activate anti-oxidant pathways (e.g.,
    upregulation of superoxide dismutase) and reduce markers
    of cellular senescence. Consequently:

    Reduced Oxidative Stress: Lower reactive oxygen species production protects tissues from damage.

    Improved Skin Elasticity: Collagen turnover increases,
    reducing fine lines and improving skin tone.

    Dosage and Administration

    The most common protocol involves subcutaneous injections administered 30–60
    minutes before bedtime. Typical dosages are:

    Sermorelin: 0.2 mg (5 IU) per injection, once nightly.

    Ipamorelin: 200–300 µg per injection, also typically once nightly.

    Some protocols include a «double-dose» on training days to aid recovery, but this is less common for the general anti-aging population. It is
    crucial to monitor blood GH and IGF-1 levels periodically, as excessive stimulation may lead to unwanted side effects such as water retention or joint pain.

    Potential Side Effects

    Because both peptides mimic endogenous signals rather than forcibly overstimulating receptors, adverse events are rare but can include:

    Injection Site Reactions: Mild redness or swelling.

    Water Retention: Especially if GH levels rise too high, leading to slight
    edema.

    Hormonal Imbalance: Rarely, prolonged use may slightly alter thyroid function; routine labs help mitigate this.

    When to Expect Noticeable Changes

    While the hormonal response is immediate, perceptible changes
    in body composition or performance typically require 4–8 weeks
    of consistent therapy. Some users report noticing improved sleep quality within a week,
    while significant muscle gain and fat loss often take 3 months for optimal effects.

    Long-Term Considerations

    Continuous use beyond six months can be beneficial, but it is advisable
    to cycle peptides every 12–18 months under
    medical supervision to prevent tolerance or diminishing returns.
    Many clinicians recommend periodic «drug holidays» of 4–6 weeks, after which a fresh course can reignite the
    body’s natural GH rhythm.

    Summary

    In summary, Sermorelin and Ipamorelin offer a gentle yet effective way to restore growth hormone production in adults experiencing age-related declines or
    athletes seeking enhanced recovery. The before state often involves fatigue, muscle loss,
    and increased fat, while after treatment many users experience
    improved energy, lean mass gain, fat reduction, better sleep, and
    overall vitality. Consistent dosing, proper injection technique, and
    regular monitoring are essential to maximize benefits
    and minimize risks.

    References:

    photos

  51. This modification allows a larger fraction of the absorbed AAS to enter the lymphatic
    system and bypass first-pass metabolism. Nonetheless, even after esterification of
    testosterone by an 11-carbon carboxylic acid group (undecanoate), oral bioavailability stays poor at 6.8% (9).
    The formulation also shows giant intra- and interindividual variation in bioavailability, making it cumbersome for
    replacement remedy. To tackle this, testosterone
    undecanoate has just lately been formulated in a self-emulsifying drug supply system (SEDDS) to additional enhance lymphatic absorption and cut back intra- and interindividual variation (10).
    Nonetheless, it needs to be dosed twice day by day
    to hold up physiological testosterone ranges throughout the day.

    Athletes also have to know that many anabolic steroids bought illegally and on-line are counterfeit and include potentially poisonous additives.
    Anabolic steroids also upregulate and enhance the variety of androgen receptors,
    thus enabling increased training depth and
    not directly contributing to increased muscle size and energy.
    Nearly one-third of people that misuse anabolic
    steroids become dependent on them. That means
    over time it begins to take larger and extra frequent doses to get the identical results.

    Anabolic steroids goal the androgen receptor, the pure
    organic receptor for testosterone and its metabolite dihydrotestosterone.
    Stimulation of the androgen receptor ends in cell
    growth, resulting in an increase in muscle measurement.

    Steroids are a category of gear that share a fat-soluble, carbon-based molecular structure.
    Not Like water-soluble minerals like potassium and sodium, steroids are saved in cell tissues.
    Vitamin D, testosterone (the naturally occurring male hormone), and a spread of anti-inflammatory compounds, such as corticosteroids,
    are steroids. Anabolic steroids are a type of synthesized
    testosterone, which is primarily supposed to stimulate muscle progress.
    Of all the substances ingested by athletes to gain a aggressive edge, anabolic steroids are
    essentially the most infamous. Steroids have taken on a broad, and sometimes inaccurate,
    range of meanings in the public consciousness, because the time period is popularly and incorrectly used to explain any type of drug that enhances athletic performance.
    Anabolic steroids are commonly smuggled from international locations the place they’re
    obtained over the counter and not utilizing a prescription, and then offered illegally within the United States.

    Individuals typically use multiple of those illegal drugs at
    the same time. Or they might take the medication in a cycle from
    no drug to a excessive dose over a interval of weeks
    to months. Androgenic results of anabolic Best Steroid for Muscle Growth use embrace —
    increased physique hair development; increased aggressiveness;
    baldness; a deepening of the voice; pimples and increased sexual drive.
    After stopping using anabolic steroids following common use,
    body might expertise issue in naturally-producing its
    personal testosterone. Anabolic-androgenic steroids (AAS) are a
    category of artificial medicine that replicate the effects of testosterone.
    The term «anabolic» refers to muscle-building, whereas
    «androgenic» refers to elevated male traits, such as facial hair and a deeper voice.

    Anabolic pathways involve the enter of energy, which is required to kind chemical
    bonds between smaller molecules to make macromolecules.

    Molecules built from anabolism are then used to build structures in the cell, and even to
    assist build new cells. Anabolism and catabolism are controlled by circadian rhythms, and both are
    essential for the event, development, and upkeep of an organism’s cells.
    Facet effects of creatine can include gaining
    weight and cramps in the stomach or muscle tissue.
    Monitor and subject events, particularly the Olympic
    sprint competitions in 1988, have been the first dramatic worldwide proof of
    the ability of steroids. Testosterone —Male hormone produced by the testes and (in small amounts) in the ovaries.
    Testosterone is liable for some masculine secondary sex traits similar to
    development of body hair and deepening voice.

    It additionally is sometimes given as part of hormone replacement
    remedy to ladies whose ovaries have been removed.
    A group of synthetic, testosterone-like hormones that
    promote muscle growth and masculinizing results. Synthetic androgens that mimic
    the consequences of the male hormone testosterone.
    Steroids affect varied physiological processes, including hormone production, irritation reduction,
    and the regulation of metabolism and immune features.

    The NHS offers comprehensive data relating to the unwanted side effects of legally-prescribed
    catabolic steroids in tablet, inhaler, nasal spray, injectable
    and cream types. Steroids which are legally prescribed
    for brief intervals in low doses do not are most likely to
    cause severe unwanted effects. In this text, we focus on steroids in additional detail, including what they’re, how they’re
    used, and the side effects of steroid use. They were banned
    by the Worldwide Olympic Committee in the 1970’s, but this did not stop their use and within the 1980’s doping became a big concern on the Olympic games and different sporting occasions.
    Drug testing got here into many sports activities and a variety
    of well-known athletes failed checks and had been banned from competing.

    However, since not all AAS customers accomplished comply with up, attrition bias may additionally (partly)
    clarify the difference. Regardless, erectile dysfunction might develop after
    an AAS cycle as a end result of the transient hypogonadal state.
    In this case a lack of libido as a result of testosterone
    deficiency usually underlies the erectile dysfunction. The mechanism for this is unclear, but, given that estradiol, independently of testosterone, additionally plays a task in regulating erectile perform (194), it would involve
    an imbalance between androgenic and estrogenic action. Erectile dysfunction may
    also be a consequence of psychological factors, as libido may rise sharply in an AAS
    person in the course of the cycle and occasionally hinder
    a healthy and mutual sexual relationship. Public discourse often contains misconceptions about anabolic steroids.
    Some imagine these medication cause exaggerated physical changes unrelated to muscle
    development.

  52. Bodybuilders often complement with fish oil to try to negate
    this side impact; nevertheless, this system is not confirmed How to Achieve Real Fat Loss be efficient.
    Fish oil, even with out the presence of anabolic
    steroids, has been found ineffective in lowering systolic blood stress in regular
    middle-aged men (7, 8). It’s essential to offer sufferers with clear guidelines on when to contact their healthcare provider primarily based on their self-monitoring results.
    This may embrace specific thresholds for weight achieve, blood pressure readings, or blood sugar ranges that warrant instant attention.
    As A Substitute, they may just cause a modest decline, thus sexual performance isn’t greatly impacted.
    Keep In Mind, whereas Deca Durabolin can help you obtain your goals, it’s
    important to consider the complete picture, including potential
    unwanted effects. In order to expertise probably the most gains on deca, it’s
    beneficial to stack it with other highly effective bulking compounds.

    If you begin to expertise any of those unwanted side effects, it’s important to talk to your physician instantly.
    They may help you figure out whether or not the drug is causing the issue and what you are able to do about it.
    If you may be vulnerable to pimples, be sure to keep a watch on your pores and skin while taking Dianabol and regulate your dosage or cycle size
    if needed. Gynecomastia is a situation that leads to enlarged
    breasts in men. Due to the aromatase enzyme being present,
    Dianabol is estrogenic and has the potential to trigger gynecomastia.
    Nevertheless, Dianabol comes with a variety of potential unwanted effects that customers
    should pay attention to which we will go over in this blog submit.
    Hypogonadism is regularly observed in individuals who abuse AAS and ought to be considered when AAS use is suspected.

    Others can take a gentle steroid such as Deca and expertise vital hairline recession after simply a few cycles.
    We discover that high estrogen increases sensitivity to sodium; thus, if a person’s sodium consumption is moderate and so they take Anadrol, they may retain extra water.
    For example, men’s physique opponents generally can take Anadrol earlier than a contest, serving to them to
    look additional full with none noticeable water retention or bloating.
    The reason why they don’t expertise water retention from Anadrol when preparing for
    a present is that the presence of high estrogen levels does not automatically assure water retention.
    Anavar will not trigger gynecomastia, because it doesn’t aromatize (inhibiting the conversion of testosterone into estrogen).

    Despite being a C-17 alpha-alkylated steroid, Anavar does not have a
    drastic effect on liver enzymes. This is most probably as a result of it being
    a light compound and the kidneys processing a half of the compound (in conjunction with the liver).

    Anavar has diuretic properties; nonetheless, in distinction to Winstrol, muscle tissue will
    remain full as only extracellular water is flushed out (not intracellular).
    We have seen ladies take Anavar safely without developing virilization signs.
    Our liver function checks present Winstrol to be hepatotoxic; thus, users
    often take a liver support complement (such as TUDCA)
    to prevent liver enzymes from rising to excessive ranges.
    Additionally, trenbolone is not estrogenic (failing to aromatize),
    making it a dry compound and thus a very desirable slicing agent.

    Dianabol can be liver poisonous, being a C-17 alpha-alkylated steroid,
    thus having to move by way of the liver to be able to become lively.
    We find such fluid causes a huge and easy look to a user’s physique, with very full and
    puffy-looking muscle tissue. By clicking «Submit,» you certify that you’ve got supplied your legal name and telephone number,
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    AddictionResource goals to present probably the most accurate, reliable,
    and up-to-date medical content to our readers.

    Our team does their finest for our readers to
    assist them keep informed about important healthcare decisions.

    In this page, the term ‘steroid’ particularly refers to anabolic androgenic steroids.

    If you’ve done a quantity of cycles already, but you’ve never used deca; anticipate to achieve an additional lbs
    of lean muscle tissue. This is actually a significant amount of muscle for a
    bodybuilder who’s been around the block a quantity of times…and has consumed numerous cocktails of steroids.
    Thus the load you’ll achieve on deca will largely be lean muscle tissue, versus water retention.
    Many people imagine deca isn’t anywhere close to
    as powerful as Dianabol for constructing muscle as a outcome
    of a user might acquire 35 lbs on Dianabol and only 20 lbs on Deca.

    Turinabol (Chlorodehydromethyltestosterone, TBol) is amongst the mildest
    Steroids on the market. In truth, it is so gentle most individuals don’t even trouble utilizing it at all!
    That stated, it still has the flexibility to extend muscle dimension, muscle strength,
    and aid in recovery. You may be prescribed
    anabolic steroids for certain medical conditions.

    While they will enhance efficiency, the potential for extreme and often irreversible unwanted effects
    outweighs the benefits for many non-medical users. «Pyramiding» is one other kind of anabolic steroid utilization people try
    to forestall dangerous side effects. You begin by taking a low dose of one or more anabolic steroids, and then improve your dosage over time.
    As Quickly As you get to a maximum dose, you cease taking
    them for a relaxation period earlier than beginning
    again. Contemplating such roles of testosterone in male human growth and well being, anabolic steroids may be important instruments
    to assist tackle sure instances of hormone deficiencies.

    Not to mention the redness and hot flashes that include all of it.» — Marisa P. You have no doubt heard the phrase ‘use it or lose it’ bandied about with regard to muscular tissues. There is a ring of reality to the assertion because our muscles will get smaller if we stop figuring out.

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